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The pillars of Ashoka are a series of columns dispersed throughout the northern Indian subcontinent, and erected by Ashoka during his reign in the 3rd century BCE. Originally, there must have been many pillars of Ashoka although only ten with inscriptions still survive. Averaging between forty and fifty feet in height, and weighing up to fifty tons each, all the pillars were quarried at Chunar, just south of Varanasi and dragged, sometimes hundreds of miles, to where they were erected. The first Pillar of Ashoka was found in the 16th century by Thomas Coryat in the ruins of ancient Delhi. The wheel represents the sun time and Buddhist law, while the swastika stands for the cosmic dance around a fixed center and guards against evil.

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All three pathways yield final products that are inactive, non-toxic, and eventually excreted by the kidneys. In the third pathway, however, the intermediate product NAPQI is toxic. NAPQI is primarily responsible for the toxic effects of paracetamol; this constitutes an example of toxication. Production of NAPQI is due primarily to two isoenzymes of cytochrome P450: CYP2E1 and CYP3A4. At usual doses, NAPQI is quickly detoxified by conjugation with glutathione.

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2) Another story aims to portray Ashoka as an evil person in order to convey the importance of his transformation into a good person upon adopting Buddhism. It begins by stating that due to Ashoka’s physical ugliness he was disliked by his father Bindusara. Ashoka wanted to become king and so he got rid of the heir by tricking him into entering a pit filled with live coals. He became famous as “Ashoka the Fierce” because of his wicked nature and bad temper. He is said to have subjected his ministers to a test of loyalty and then have 500 of them killed for failing it. He is said to have burnt his entire harem to death when certain women insulted him. He is supposed to have derived sadistic pleasure from watching other people suffer. And for this he built himself an elaborate and horrific torture chamber where he amused himself by torturing other people. The story then goes on to narrate how it was only after an encounter with a pious Buddhist monk that Ashoka himself transformed into “Ashoka the pious”. A Chinese traveler who visited India in the 7th century CE, Xuan Zang recorded in his memoirs that he visited the place where the supposed torture chamber stood.

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